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盐酸-5-甲基-8-羟基喹啉的晶体结构与生物活性研究

Crystal Structure and Biological Activity of N-protonation-5-methyl-8-hydroxyquinolin Chloride

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【作者】 曹国标刘胜利杨涛

【Author】 CAO Guo-biao~1,LIU Sheng-li~2,YANG Tao~1(1.Department of Chemistry and Life Science,Ankang School,Ankang 725000,China;2.School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,China)

【机构】 安康学院化学与生命科学系湖南科技大学化学化工学院安康学院化学与生命科学系 陕西安康725000湖南湘潭411201陕西安康725000

【摘要】 5-甲基-8-羟基喹啉(1)经盐酸酸化成1.HC l,其水溶性增强。研究了1.HC l对蚕豆有丝分裂的影响,结果表明,1.HC l更能有效地促进细胞的有丝分裂。培养了单晶1.HC l。在293 K,用单晶X-射线衍射法对1.HC l进行了结构表征。1.HC l晶体属于单斜晶系,空间群P21/c,a=0.73770(9)nm,b=1.57126(19)nm,c=0.81414(10)nm,β=101.329(2),°V=0.9253(2)nm3,Z=4,Dc=1.404 g.cm-3,F(000)=408,μ=0.368 mm-1,R1=0.0393,wR2=0.1091。

【Abstract】 5-Methyl-8-hydroxyquinolin(1) was acidified with hydrochloric acid to form 1·HCl with higher water-solubility.The effect of 1·HCl on the kary-omitosis of the horsebean was investigated.It was found that the 1·HCl was better than 1 in promoting the cell to have a fission.The crystal structure of 1·HC was determined by single crystal X-ray diffraction at temperature of 293 K.The crystal of the 1·HCl belongs to monoclinic system,space group P21/c with a=0.73770(9) nm,b=1.57126(19) nm,c=0.81414(10) nm,β=101.329(2)°,V=0.9253(2) nm3,Z=4,Dc=(1.404) g·cm-3,F(000)= 408,μ=0.368 mm-1,R1=0.0393,wR2=0.1091.

【基金】 陕西省教育厅中青年科技人才培养资助项目(06JK362)
  • 【文献出处】 合成化学 ,Chinese Journal of Synthetic Chemistry , 编辑部邮箱 ,2006年06期
  • 【分类号】O626
  • 【被引频次】1
  • 【下载频次】118
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