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盐酸-5-甲基-8-羟基喹啉的晶体结构与生物活性研究
Crystal Structure and Biological Activity of N-protonation-5-methyl-8-hydroxyquinolin Chloride
【摘要】 5-甲基-8-羟基喹啉(1)经盐酸酸化成1.HC l,其水溶性增强。研究了1.HC l对蚕豆有丝分裂的影响,结果表明,1.HC l更能有效地促进细胞的有丝分裂。培养了单晶1.HC l。在293 K,用单晶X-射线衍射法对1.HC l进行了结构表征。1.HC l晶体属于单斜晶系,空间群P21/c,a=0.73770(9)nm,b=1.57126(19)nm,c=0.81414(10)nm,β=101.329(2),°V=0.9253(2)nm3,Z=4,Dc=1.404 g.cm-3,F(000)=408,μ=0.368 mm-1,R1=0.0393,wR2=0.1091。
【Abstract】 5-Methyl-8-hydroxyquinolin(1) was acidified with hydrochloric acid to form 1·HCl with higher water-solubility.The effect of 1·HCl on the kary-omitosis of the horsebean was investigated.It was found that the 1·HCl was better than 1 in promoting the cell to have a fission.The crystal structure of 1·HC was determined by single crystal X-ray diffraction at temperature of 293 K.The crystal of the 1·HCl belongs to monoclinic system,space group P21/c with a=0.73770(9) nm,b=1.57126(19) nm,c=0.81414(10) nm,β=101.329(2)°,V=0.9253(2) nm3,Z=4,Dc=(1.404) g·cm-3,F(000)= 408,μ=0.368 mm-1,R1=0.0393,wR2=0.1091.
【Key words】 hydroxyquinoline; crystal structure; hydrogen bond; biological activity;
- 【文献出处】 合成化学 ,Chinese Journal of Synthetic Chemistry , 编辑部邮箱 ,2006年06期
- 【分类号】O626
- 【被引频次】1
- 【下载频次】118