【摘要】 以香草醛(或对羟基苯甲醛)和丙二酸为原料,经Knoevenagel反应、酯化、氧化银为氧化剂的自由基仿生氧化偶联反应合成了新木脂素3a,3b。3a,3b分别与异维A酸酯化,合成了两种新型的异维A酸新木脂素酯4a和4b。用1H NMR,IR和MS对它们的结构进行了表征。研究了异维A酸酯的反应机理。更多还原

【Abstract】 Neolignans（3a,3b） were synthesized via Knoevenagel reaction,esterification and Ag₂O-catalyzed biomimetic oxidative coupling from vanillin or p-hydroxylbezaldehyde and malonic acid.Two novel neolignan-13-cis-retinoates（4a,4b） were obtained by the reaction of 3a,3b with 13-cis-retinotic acid and their structures were characterized by ¹H NMR,IR and MS.The reaction mechanism of 13-cis-retinoate was studied.更多还原