【摘要】 目的:探讨抑制素B(Inhibin B)和胰岛素样生长因子Ⅱ(IGF-Ⅱ)与多囊卵巢综合征(PCOS)发病机制之间的关系。方法:采用酶联免疫吸附试验(ELISA)测定20例PCOS妇女和10例输卵管性因素不孕妇女控制性超排卵(COH)用药前基础血清,用药过程中(注射HCG前)血清和取卵日卵泡液(FF)中的Inhibin B和IGF-Ⅱ水平,同时采用放射免疫分析法(RIA)测定其中其他性激素水平。结果:用药后PCOS组血清Inhibin B值和IGF-Ⅱ值高于对照组(P>0.05);PCOS组卵泡液中Inhibin B和IGF-Ⅱ显著高于对照组(P<0.01);PCOS组卵泡液中IGF-Ⅱ与Inhibin B呈显著正相关(r=0.56,P<0.01)。结论:Inhibin B与IGF-Ⅱ作为重要的卵巢内局部自-旁分泌调节因子,可能参与了PCOS的发病过程。更多还原

【Abstract】 Objective: To investigate the significance of inhibin B and insulin-like growth factor Ⅱ(IGF-Ⅱ)in the pathogenisis of polycystic ovarian syndrome(PCOS).Methods: The levels of inhibin B,IGF-Ⅱ and other endocrine factors in the serum and follicular fluid(FF) were assayed by ELISA and RIA before and after controlled ovarian hyperstimulation(COH).Results: After COH,the serum levels of inhibin B(P>0.05) and IGF-Ⅱ(P>0.05)were higher in the PCOS group;the FF levels of inhibin B(P<0.01) and IGF-Ⅱ(P<0.01)of the PCOS group were obviously higher than in the control;a positive correlation was found between the FF levels of inhibin B and IGF-Ⅱ in PCOS group(r=0.56,P<0.01).Conclusion: The serum and FF levels of inhibin B and IGF-Ⅱ of PCOS patients undergoing COH were obviously different from the controls,which confirmed the role of inhibin B as well as IGF-Ⅱ in the pathogenisis of PCOS.更多还原