【摘要】 目的探讨羟丙基纤维素与丝裂霉素联合膀胱灌注在预防浅表膀胱癌术后复发中的机制和疗效。方法36例浅表性膀胱癌患者均行TURBT手术后,随机分为HPC-MMC联合组和单纯MMC组,分别用1%HPC-MMC和MMC行膀胱灌注,然后比较两组的肿瘤复发率和不良反应发生率并进行统计学分析。结果HPC-MMC组的肿瘤复发率为2/18(11.11%),MMC组的肿瘤复发率为6/18(33.33%),两组间比较差异有显著性意义(P<0.05)。HPC-MMC组的不良反应发生率为6/18(33.33%),MMC组不良反应发生率为7/18(38.88%),两组间比较差异无统计学意义(P>0.05)。结论羟丙基纤维素与丝裂霉素联合膀胱灌注可以提高化疗效果,降低肿瘤复发率同时并不增加灌注的不良反应,值得临床推广。更多还原

【Abstract】 Objective To investigate the possible mechanism and the efficacy of combined intravesical instillation of the MMC and HPC in the prophylaxis of local recurrence after resection of bladder cancer. Methods 36 patients with urinary bladder tumor were observed in the present study, 18 patients were administered with 1% HPC-MMC instilled into the urinary bladder and the other were administered conventional aqueous MMC after TURBT. The recurrence rate and side effect rate were compared in both group. Results The recurrence rate of MMC group is 33.33%(6/18), the recurrence rate of HPC-MMC group is 11.11%(2/18), the side effect rate of MMC group is 38.88%(7/18), the side effect of HPC-MMC group is 33.33%(6/18). Conclusions Combined intravesical instillation of the MMC and HPC could keep longer MMC in urine and could be effective against local recurrence of bladder cancer without additional side effects.更多还原