【摘要】 目的探讨甲状腺球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)和甲状腺球蛋白(TG)在弥漫性甲状腺肿(G raves病)甲亢和结节性甲状腺肿甲亢中的诊断意义。方法对初次临床诊断为甲亢的患者,进行甲状腺ECT扫描,同时用化学发光法检测患者血清的TG-Ab、TPO-Ab、TG、促甲状腺素(TSH)、总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT4)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)水平。其中G raves病甲亢(Ⅰ组)159例,多结节性甲状腺肿甲亢(Ⅱ组)37例,单发结节性甲状腺肿(Ⅲ组)28例。结果Ⅰ组的TG-Ab、TPO-Ab的阳性率分别为58%和75%,明显高于Ⅱ组(47%、43%)、Ⅲ组(42%、37%),而Ⅰ组TG的阳性率(37%)则明显低于Ⅱ组(57%)、Ⅲ组(53%)。三组的TSH水平无显著性差异(P>0.05),而Ⅰ组甲状腺激素(TT3、TT4、FT3、FT4)分别与Ⅱ组、Ⅲ组比较(秩和检验),存在显著性差异(P<0.05)。结论初次诊断的G raves甲亢患者甲状腺功能亢进程度较结节性甲状腺肿甲亢严重,且大部分患者TPO-Ab阳性。更多还原

【Abstract】 Objective To observe dignostic value of combining tests of thyroid auto-antibodies in Graves’s hyperthyroidism and hyperthyroidism with nodular gotier.Methods Diagnose the character of nodular goiter in thyroid imagine by ECT,the technology of luminescence immunoassay was used to measure concentration of TG、 anti-TG Ab、 anti-TPO Ab、 TT3、 TT4、 FT3、 FT4 and TSH in the patients with hyperhyroidism.Results The positive rates for TG-Ab and TPO-Ab were 58% and 75% in group Ⅰ,and significantly higher than that in group Ⅱ(47%、43%)and group Ⅲ(42%、37%).The positive rate for TG was 37% in group Ⅰ and significantly lower than that in group Ⅱ(57%) and group Ⅲ(53%).There was no significant difference among 3 groups in the level of TSH(P>0.05),the levels of thyroid hormones(TT3、TT4、FT3、FT4)were significantly different between group Ⅰ and group Ⅱ and Ⅲ(P<0.05).Conclusion Hyperthyroidism in patients with Graves disease is more severe in patients with nodular goiter.更多还原