【摘要】 目的:从酸枣仁提取出多糖样品并观察其对实验小鼠是否具有镇静催眠活性。方法:采用水提醇沉法从酸枣仁中提取出多糖样品,并采用自主活动法、玻璃倾斜法以及翻正反射法测定了它对正常小鼠的镇静、协调和催眠作用。结果:酸枣仁多糖没有明显抑制正常小鼠的自由活动和协调运动,没有延长巴比妥钠阈上剂量小鼠睡眠时间以及增加巴比妥钠阈下剂量小鼠睡眠只数的作用,相对于空白组均无显著差异P>0.05,无统计学意义。结论:酸枣仁多糖不具有或只具有微弱的催眠效果。这在国内外是首次报道。更多还原

【Abstract】 Semen Ziziphus jujube (SZJ), the seeds of Ziziphus jujuba Mill var.spinosa, was a traditional Chinese medicine used for its action on insomnia. The aim of the study was to investigate polysaccharides, induced sedative and hypnotic effects by using sodium barbital as an index. Polysaccharides were orally administered to mice separately at 0.15g/kg for several days before the behavioral evaluation and barbituric-hypnosis test. Results showed that polysaccharides never caused a significant decrease of spontaneous motion, or significant prolongation of sleeping time and sleeping number induced by coeliac injection of sodium barbital(40 mg/kg, ip, subthreshold dose and 50 mg/kg, ip, superthreshold dose). Polysaccharides showed an invisible effect on the sedative and hypnotic (P>0.05).更多还原