【摘要】 目的研究倍他司汀对荷瘤肝癌小鼠生存时间及肉瘤瘤重的影响。方法采用小鼠移植性肿瘤肝癌H22、肉瘤S180的体内试验方法,以环磷酰胺为阳性对照药,观察倍他司汀不同剂量组对荷瘤肝癌H22小鼠生存天数、生命延长率及荷瘤S180小鼠瘤重、抑瘤率、胸腺和脾脏系数的影响。结果6.67mg/kg、13.33mg/kg、26.67mg/kg倍他司汀组的肝癌H22小鼠生命延长率分别为5.48%、8.22%、16.44%,与剂量呈一定的正相关,26.67mg/kg倍他司汀组的生存天数显著延长(与生理盐水组比较,P<0.05);6.67mg/kg、13.33mg/kg、26.67mg/kg倍他司汀组的S180小鼠抑瘤率分别为6.83%、9.13%、18.05%,与剂量呈一定的正相关,26.67mg/kg倍他司汀组的S180小鼠瘤重显著减少(与生理盐水组比较,P<0.05)。结论倍他司汀对荷瘤肝癌H22小鼠有延长生存时间的作用,对S180肉瘤有抑制作用。更多还原

【Abstract】 Objective To study the effects of betahistine on survival time in mice with hepatoma and turmor weight in mice with sarcoma.Methods Hepatoma H 22 and sarcoma S 180 were transplanted to mice and the effects of betahistine were observed.Results The mice bearing H 22 were treated with 6.67mg/kg,13.33mg/kg or 26.67mg/kg betahistine for 7 days,the life prolongation rate was 5.48%,8.22% and 16.44%,respectively,which was positively correlated with the dosage. The survival time of 26.67mg/kg betahistine group was significantly increased compared with the control group（P<0.05）.The mice bearing S 180 were treated with 6.67mg/kg,13.33mg/kg or 26.67mg/kg Betahistine for 7 days and the tumor weight was decreased ,the inhibition rate was 6.83%,9.13% and 18.05%,respectively,which was positively correlated with the dosage. The turmor weight of 26.67mg/kg betahistine group was significantly decreased compared with the control group（P<0.05）.Conclusion The results suggest that betahistine can prolong the survival time in mice with hepatoma H₂₂ and inhibite tumor-growth in mice with sarcoma S₁₈₀. .更多还原