【摘要】 目的:探讨TH1/TH2应答与急性心肌梗死发作的关系。方法:采用双抗体夹心酶联吸附法(ELISA),测定27例急性心肌梗死及29例健康者血清IFN-r、TNF-а及IL4、IL-6、IL-10、TGF-β1水平。结果:(1)急性心肌梗死患者血浆中IFN-r水平低于正常人,且治疗前低于治疗后(P<0.01);治疗前病人血清中TNF-а水平与正常人比较无明显统计学意义,但治疗后高于治疗前,且有统计学意义(P<0.001)。(2)心肌梗死患者在治疗前后血浆IL-6水平均明显高于正常人(P<0.05),且治疗后明显低于治疗前(P<0.01);正常人血清中TGF-β1水平明显高于病人,且治疗后高于治疗前(P<0.05)。IL-4、IL-10水平在各组标本无明显差异。结论:心肌梗死急性发作与免疫应答有关,并可能向TH2应答偏移。更多还原

【Abstract】 Objective: To investigate the pathophysiologic significance of serum level changes of some cytokines in acute myocardial infarction(AMI).Methods: The serum levels of IFN-γ,TNF-α,TGF-β,and IL-4,IL-6,IL-10 in 27 cases of AMI and 29 healthy people(as control) were measured with a sensitive sandwich enzyme-linked immunosorbent assay(ELISA).Results:(1) Levels of IFN-γ were higher in control group than those in AMI group.Levels of TNFαin AMI group were significantly higher after treatment than before(P<0.001).(2) Levels of IL-6 in AMI group were lower after treatment than before(P<0.01),and were both higher than those of the controls(P<0.05).TGF-β1 Levels in AMI group were lower than those of healthy control,and were higher after treatment than before the treatment.No significant difference was found among the levels of IL-4 and IL-10 in both groups.Conclusions: The acute seizure of myocardial infarction relates to immunological response,and might have a bias trend to TH2 response.更多还原