【摘要】 目的:探讨树鼩肝癌形成过程中红细胞免疫黏附肿瘤细胞功能的变化。方法:将实验树鼩随机分为4组:黄曲霉毒素(AFB1)组(A组)、乙型肝炎病毒(HBV)+AFB1组(B组)、HBV组(C组),空白对照组(D组)。实验过程中所有动物定期抽血,用自然肿瘤红细胞花环试验(NTERT)检测树鼩的红细胞免疫黏附功能。结果:在实验过程中的不同阶段,各实验组的红细胞免疫黏附肿瘤细胞功能与对照组比较均明显不同。结论:在树鼩肝癌形成过程中,NTERT所反映的红细胞免疫功能,可灵敏地反映该过程不同时期的变化。更多还原

【Abstract】 Objective:To observe immune adhesive function of erythrocyte on tumor cells during tree shrew’s hepatocarcinogenesis.Methods:Experimental tree shrews were divided into 4 groups: Group A were fed with AFB₁,Group B were first infected with HBV then treated with AFB₁ as the animals in Group A,and Group C were infected with HBV only and Group D were raised normally.Neither HBV nor AFB₁ was given.The blood of all the animals in each group was tested regularly by the method of natural tumor erythrocyte rosette test（NTERT）.Result:The function of immune adhesion of erythrocyte for tumor cells in Group A,B and C were predominately higher than that in Group D during the early stage but lower in late stage of tree shrew’s hepatocarcinogenesis.Conclusion:The function of immune adhesion of erythrocyte for tumor cells did work during hepatocarcinogenesis induced by AFB₁ and HBV.The method of NTERT was simple,repeatable and inexpensive.It can sensitively represent the changes on immune function of erythrocyte in animal experiment.更多还原