【摘要】 采用熔融法制备了NaO–CaO–SiO₂–P₂O₅–B₂O₃玻璃,用质量损失分析、pH值测定和X射线衍射、电子显微镜以及电感耦合等离子体离子浓度分析法表征玻璃与稀K2HPO4溶液的类生物反应,研究了这类玻璃的生物活性和生物降解性。结果表明当玻璃中B₂O₃/SiO₂的摩尔比为31时,生物活性较好。随着B₂O₃与SiO₂的摩尔比减小,玻璃的降解速度变慢,获得的羟基磷灰石结晶度较低。利用此特性可控制生物玻璃的降解速度,从而与骨细胞生长速度相匹配。因此,此类硼硅酸盐生物活性玻璃有望在硬组织工程支架材料中得到应用。更多还原

【Abstract】 Glasses in an NaO–CaO–SiO₂–P2O5–B2O3 system were prepared by a melting process. The reaction of these glasses with dilute K2HPO4 solution was characterized by mass loss analysis, pH value measurement, X-ray diffraction, scanning electron micros-copy and inductance coupling plasma ion analysis. The bioactivity and biodegradability of these glasses were investigated extensively. The results show that the glass with the molar ratio of B2O3 to SiO₂ of 3:1 has the best bioactivity of these glasses. The biodegradability rate and crystallinity of hydroxyapatite of the glasses decrease with the decrease of the molar ratio of B2O3 to SiO₂. This implies that the biodegradability can be controlled by regulating the glass composition, and can therefore be adjusted to match the growth rate of bone cells. Therefore, this kind of bioactive borosilicate glass shows promise for application in the fabrication of scaffolding in hard tissue engineering.更多还原