【摘要】 目的：探讨BNP对稳定型冠状动脉疾病患者的预后判断价值。方法：对186例稳定型冠状动脉疾病患者入院时测定其BNP值,并行冠状动脉及左室造影,平均随访16个月,观察其死亡率,对BNP与死亡率相关性进行统计学分析。结果：随访期间15例(8．0%)死亡。存活者的BNP均值显著低于死亡者(120pg/ml对386 pg/ml,P＜0．01)。BNP水平位于最高的四分位数的患者与低四分位数的患者相比,具有高龄、低左室射血分数(LVEF)等特点,更可能患有心肌梗死及糖尿病等病史。在多变量COX回归模型中,BNP水平位于第四个四分位数的患者与第一个四分位数相比,其死亡的危险比为2．4(95%CI：1．5～4．0,P＜0．001)。结论：BNP是稳定型冠状动脉疾病患者预后不良的指标,其预后判断价值可能大于常规的危险因素。更多还原

【Abstract】 Objective:To evaluate the relationship between B-type natriuretic peptide(BNP) and mortality of all causes in patients with stable coronary heart disease.Methods:BNP was meas- ured in baseline serum samples from 186 patients refered for angiography and left ventricular ejection fraction(LVEF),the rate of death of all causes was determined after a median follow-up of 16 months.Statistical analysis was done.Results:At follow-up period,15 patients had died.The me- dian BNP level was significantly lower among patients who survived than among those who died (120pg/ml vs 386pg/ml,P＜0.01).Patient with BNP levels in the highest quartile were older,had a lower left ventricular ejection fraction(LVEF),and were more likely to have a history of myocardial infarction and diabetes than patients with BNP levels in the lowest quartiles.In a multivariable COX regression model,the hazard ratio of death from any cause for the patients with BNP levels in the fourth quartile as compared with those patients with those in the first quartile was 2.4(95% CI:1.5～4.0,P＜0.001 ).Conclusions:BNP is a marker of mortality in patients with stable coronary disease and provides more prognostic information than conventional cardiovascular risk factors and the degree of left ventricular systolic dysfunction.更多还原