【摘要】 RNA干扰(RNAinterference,RNAi)是通过导入与靶基因序列同源的双链RNA(dsRNA)诱导的序列特异性的转录后基因沉默现象(posttranscriptionalgenesilencing,PTGS)。目前,RNA的作用机制已经基本明确,并显示出广阔的应用前景。作者主要从癌症、病毒和细菌性疾病、寄生虫病、呼吸道疾病和神经性疾病几个方面综述RNAi在基因治疗上的研究新进展。更多还原

【Abstract】 RNA interference(RNAi) induce a special post-transcriptional gene silencing(PTGS) by introducing a double-stranded RNA(dsRNA) which homology to the target gene.At present,the mechanism of RNAi has been understangded and has shown a widely application prospect.This review manly summarizes RNA interference’s new research progress in gene therapy from the aspects of cancers, viruses and,bacteria diseases, parasites diseases ,respiratory diseases and neurological diseases更多还原