【摘要】 目的:观察单纯饮食改变治疗大鼠非酒精性脂肪性肝炎(NASH)的作用。方法:30只SD大鼠随机分为3组(每组n=10):正常组喂普通饲料;模型组喂高脂饲料;饮食治疗组在高脂饮食12周后恢复正常饲料喂养。16周后处死动物。结果:正常饮食能显著降低造模大鼠的体重、肝指数、转氨酶,还能改善肝脏脂肪变性和炎症坏死的程度。结论:单纯恢复正常饮食即可治疗大鼠NASH。更多还原

【Abstract】 Objective: To investigate the therapeutic effects of diet change on Non-alcoholic steatohepatitis(NASH) by means of rat model. Methods:Thirty Male SD rats were divided into three groups. The controlled group(n=10)were fed with normal diet;the NASH model group were fed with high-fat diet ; The diet therapy group were fed with high-fat diet for twelve weeks .then fed with normal diet. Sixteen weeks later, all rats were sacrificed. Results: The diet therapy group had a beneficial effect on lowing weight, liver index, serum aminotransferase activity. A significant improvement in some histological features such as steatosis and inflammation were also observed. Conclusion: Diet therapy is effective in ameliorating NASH in rats.更多还原