【摘要】 CREB结合蛋白(cAMPresponseelementbindingproteinbindingprotein,CBP)是一种重要的转录辅激活因子,具有高度保守的序列,能够与300多种转录因子相结合,被认为是哺乳动物基因转录调控中的关键位点。CBP在转录活化过程中主要起乙酰转移酶、桥梁以及支架作用。随着对脂代谢研究的深入,发现很多参与脂代谢的核转录因子(如PPAR、CREB、C/EBPs及SREBPs等)在作用于相应靶基因时都需要CBP的参与,因此CBP可能作为脂代谢的关键调节点。更多还原

【Abstract】 CREB binding protein (CBP) is a crucial transcriptional coactivator, which contains highly conserved sequence and can interact with about 300 kinds of transcription factors, and is considered to be the key point of the regulation of mammalian genes transcription. CBP functions as acetyltransferase, bridge and scaffold in transcriptional activation. The study of lipid metabolism has found that several transcription factors related to lipid metabolism, such as PPAR, CREB, C /EBPs and SREBPs, were associated with CBP. So we hypothesized that CBP is the key regulator of lipid metabolism.更多还原