【摘要】 人肠上皮细胞表面抗原A33是一种在人胃肠道上皮细胞特异性表达的跨膜糖蛋白,在95%以上的大肠癌、63%的胃癌和50%的胰腺癌中表达,而在其它组织或其它肿瘤细胞中鲜有表达。近年来就A33的组织特异性表达模式进行了深入的研究,揭示了与A33的特异性表达相关的特异性启动子和组织特异性转录因子(GKLF、CDX1)。A33抗体导向下的直肠癌放射免疫治疗已成为单克隆抗体(monoc lonal an-tibody,MCAB)导向治疗研究领域的热点,且已经进入Ⅰ期放射免疫治疗临床实验。更多还原

【Abstract】 The human intestine tissue specific antigen A33 is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily.It is expressed in more than 95% of human colon cancers,63% of gastric cancers and 50% of pancreatic cancers,and it has not been found to express in other tissues or cancers.Over the past years,a lot of work has been done on the tissue-specific expression profile,and scientists have identified the promotor and transcription factor(GKLF、CDX1) that are associated with specific expression of A33.Advances have been made in the research of monolclonal antibodies for radioimmunotherapy and now the study is in the phase I trial in patients with advanced colorectal carcinoma.更多还原