【Abstract】 Lidocaine is often administered intravenously(1.5mg/kg) to suppress airway reflexes associated with tracheal intubation or tracheal suction.Lidocaine given as an aerosol can provoke an initial bronchoconstriction.,but this bronchoconstriction can be prevented by pretreatment with intravenous lidocaine.Combined intravenous lidocaine and inhaled salbutamol protect against brohcbial hyperreactivity more effectively than lidocaine or salbutamol alone.Lidocaine markedly reduces reflex bronchoconstriction,but has little effect on the initiated by allergic mediators.Lidocaine may worsen histamine-induced bronchoconstriction by decreasing plasma concentrations of catecholamines,this may have therapeutic implications for patients with acute asthma or anaphylactic shock who may become dependent on circulating catecholamines.The effects of Lidocaine on attenuation of bronchial hyperreactivity and the effects of topical airway anesthesia are two independent mechanisms.更多还原