【摘要】 目的分析ICU患者中输血相关性移植物抗宿主病(TA_GVHD)的发病情况并对影响因素进行探讨。方法女性患者输血前后自身对照,采取静脉血样,用PCR技术进行TA_GVHD插入基因片段及人Y染色体特异基因荧光检测。结果26例患者中,有14例患者输血后出现Y染色体特异基因片段检测阴性而同时TA_GVHD插入基因片段检测阳性的结果,发生率为53.8%。结论ICU中TA_GVHD发生率较文献报道明显增多,可能与ICU中危重症患者的免疫功能低下等有关。更多还原

【Abstract】 Objective To study transfusion associated graft versus host disease(TA-GVHD) in ICU.Methods The insert gene region of TA-GVHD and specific gene region of the Y chromosome was detected using PCR technique.Results Of 26 patients,positive insert gene region of TA-GVHD and negtive specific gene region of the Y chromosome were detected in 14 cases after transfusion.The incidence of TA-GVHD was 53.8%.Conclusions The incidence of TA-GVHD was higher than that from the literature and that may be related to the immune suppression.更多还原