【摘要】 目的:探讨氧化性损伤在血管性认知障碍(VCI)发病中的作用。方法:测量45例VCI患者(VCI组)和26例正常人(对照组)血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶(NOS)浓度。结果:与对照组比较,VCI组血清SOD、NO、NOS浓度明显降低(P<0.01),血清MDA浓度明显增高(P<0.01);VCI组血清NO浓度与MMSE值正相关(r=0.574,P<0.01)。结论:氧自由基所致的损伤和机体抗氧化系统保护功能的减弱可能在VCI的病理过程中起重要作用;NO和NOS可能参与VCI的发病过程。更多还原

【Abstract】 Objective: To explore the characteristics of free radical metabolism, nitric oxide and nitric oxide synthase in vascular cognitive impairment. Methods: The levels of superoxide dismudase (SOD), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) of blood serum were determined in 45 patients with vascular cognitive impairment (VCI) and 26 normal aged controls. Results: When compared with controls, SOD, NO and NOS were lower and MDA higher significantly in VCI patients (P<0.01). More importantly, the levels of NO were positively correlated to the scores of MMSE (r=0.574, P<0.01). Conclusions: the injury of free radicals and the decrease in protective anti-oxidation enzyme system possibly played important roles in the development of VCI. NO may be involved in VCI development.更多还原