【摘要】 利用吸收光谱、荧光光谱、DNA热变性研究了鬼臼酰肼金属配合物与小牛胸腺DNA之间的相互作用。在金属配合物的存在下,DNA的紫外吸收光谱产生了明显的减色效应。实验结果表明,鬼臼酰肼金属配合物与DNA之间主要以嵌入方式相结合。更多还原

【Abstract】 The interaction between the metal complex of hydrazide of podophyllic acid and calf thymus (CT) DNA was studied by using absorption spectra, fluorescence spectra and DNA heat denaturation. It was found that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of the metal complex of hydrazide of podophyllic acid compared with that in the absence of the metal complex. All the experimental results show that the intercalation mode was proved to exist between HDPP-Ni complexes and CT DNA.更多还原