【摘要】 通过二乙三胺五乙酸单环酸酐(DTPA-MA)分别与L-赖氨酸的十八酯、十六酯、十四酯和十二酯的双酰化反应,制得四种含有双DTPA螯合单元的新型配体。它们与GdCl3.6H2O配合得到相应的双核钆(Ⅲ)配合物。表征了配体和配合物的结构,测试了配合物的纵向弛豫效能(R1)。结果表明:这四种新钆配合物的R1都高于Gd-DTPA。更多还原

【Abstract】 To look for new MRI（magnetic resonance imaging） contrast agents with higher relaxivity as well as liver-selecsivity,four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl,hexadecanyl,tetradecanyl and dedecanyl L-lysine with diethylenetriaminepentaacetic acid mono-anhydride（DTPA-MA）,respectively.The corresponding dimeric Gd（Ⅲ） complexes were gained by the reaction of these ligands with GdCl₃·6H₂O.All ligands and complexes were characterized by FTIR,（（）¹H NMR） and elemental analysis.The longitudinal relaxation time（T₁） was measured,and relevant longitudinal relaxivity（R₁） of these neatral binuclear Gd（Ⅲ） complexes is: 6.48,6.02,5.76 and 5.68 L·mmol^-1·s^-1,respectively,and all are higher than that of Gd-DTPA(4.98 L·mmol^-1·s^-1)（300 MHz）.更多还原