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四物汤对环磷酰胺所致贫血小鼠红细胞免疫功能的影响

Experimental study of SiWu Tang on red cell immunity in mice with Anemia induced by Cyclophamide

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【作者】 张文平; 陈惠群; 曾雪英; 张文书;

【Author】 ZHANG Wen-ping~1,CHEN Hui-qun~2,ZENG Xue-ying~1,ZHANG Wen-shu~3(1.Department of Pathogenic Biology of Gannan Medical College;2.Department of Obsterics and Gynecology,GanZhuo Municipal hospital;3.Laboratory Animal Center,Gannan Medical College,Gangzhuo JiangXi 341000)

【机构】 赣南医学院病原生物学教研室; 赣州市立医院妇产科; 赣南医学院实验动物中心 江西赣州341000; 江西赣州341000;

【摘要】 目的:研究四物汤对环磷酰胺致小鼠“贫血”模型红细胞免疫功能的影响。方法:腹腔注射环磷酰胺建立小鼠“贫血”动物模型,同时给小鼠灌服不同剂量四物汤,采用酵母菌花环法,测定四物汤对小鼠红细胞免疫粘附功能指标的影响。结果:四物汤能明显提高“贫血”小鼠的红细胞C3b受体(RBC-C3bR)花环率,降低红细胞免疫复合物(RBC-IC)花环率,与模型对照组比较差异有显著性(P<0.01)。结论:①“贫血”小鼠的红细胞免疫功能呈明显低下状态。②古方四物汤具有恢复红细胞免疫功能的作用。

【Abstract】 Objective: To study the effect Si Wu Tang of on red blood cell(RBC) immunity in mice with Anemia induced by(Cyclophamide).Methods: This Anemia model was made in mice by i.p.Cyclophamide.The targets of RBC immune functions of Anemia mice were detected by using yeast rosette method after treatment with different doses of SiWu Tang orally.Results: SiWu Tang could markedly elevate RBC-C3b rosette rate and depress RBC immunocomplex rosetter rate of mice when compared with model control group(P<(0.01)).Conclusion: ①The RBC immune function was low in Anemia mice;②The SiWu Tang was able to increase the RBC(immune) function.

  • 【文献出处】 赣南医学院学报 ,Journal of Gannan Medical University , 编辑部邮箱 ,2006年01期
  • 【分类号】R285
  • 【被引频次】19
  • 【下载频次】186
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