【摘要】 肿瘤坏死因子(TNF)-α通过其细胞膜上的受体在免疫和非免疫系统中发挥着许多不同作用。研究表明,糖尿病视网膜病变患者血清及玻璃体视网膜局部均可检测到TNF-α,且随病变进展血清中TNF-α水平升高。推测TNF-α可能通过直接损伤血—视网膜屏障,提高视网膜血管通透性,诱导其他细胞因子释放,提高靶细胞的反应性,以及诱导、加重胰岛素抵抗的产生,在糖尿病视网膜病变的发生、发展中起非常重要的作用。更多还原

【Abstract】 Tumor necrosis factor(TNF)-α exerts numerous functions in the immune and non-immune system through its receptors located on the cellular membrane. Some evidences show that TNF-α is detected in the serum, vitreous body and retina of diabetic patients. Moreover, the levels of TNF-α in the serum step up following the development of diabetic retinopathy(DR). TNF-α might be associated with DR by directly impairing the blood-retinal barriers, promoting retinal vessels′ permeabilities, increasing the secretion of other cytokines and their reactivities towards the target cells, inducing and aggravating the insulin resistance, etc.更多还原