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比较比索洛尔与卡维地洛治疗充血性心力衰竭的多中心随机双盲开放平行对照临床研究

Parallel,randomized,open-label,blind endpoint clinical trial of comparison of bisoprolol and carvedilol in the treatment of chronic left heart failure

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【作者】 汪芳; 李一石; 胡大一; 柯元南; 李天德; 陆国平; 吴宗贵; 陆凤翔; 陈君柱; 伍卫; 吴书林; 樊朝美; 边文彦; 顼志敏; 明广华; 蒋文;

【Author】 WANG Fang~1, LI Yi-shi~1, HU Da-yi~2, KE Yuan-nan~3,LI Tian-de~4,LU Guo-ping~5, WU Zong-gui~6,LU Feng-xiang~7, CHEN Jun-zhu~8,WU Wei~9,WU Shu-lin~ 10 , FAN Chao-mei~1,BIAN Weng-yan~1, XU Zhi-min~1,MING Guang-hua~1,JIANG Wen~1 (1.Centerfor Clinical Pharmacology,Cardiovascular Institute and Fuwai Heart Hospital, Chinese Acadeny of Medical Sciences and Peking Union Medical College,Beijing 100037,China;2.People’s Hospital, Peking University,Beijing 100044,China;3.China -Japan Friendship Hospital,Beijing 100029,China;4.General Hospital of PLA,Beijing 100853,China;5.Shanghai Ruijing Hospital,Shanghai 200025,China;6.Shanghai Changzheng Hospital,Shanghai 200003,China;7.The First Affiliated Hospital of Nanjing Medical University, Nanjing210029,China;8.The First Affiliated Hospital of Zhejiangl University,Hangzhou 310003,China;9.Sun Yat-Sen University,Guangzhou 510120,China;10.Guangdong Province People’s Hospital,Guangzhou 510080,China)

【机构】 中国医学科学院、中国协和医科大学阜外心血管病医院临床药理中心; 北京大学人民医院; 北京中日友好医院; 解放军总医院; 上海瑞金医院; 上海长征医院; 南京医科大学附属医院; 浙江大学第一附属医院; 中山大学第二附属医院; 广东省人民医院; 中国医学科学院、中国协和医科大学阜外心血管病医院临床药理中心 北京; 100037; 北京; 北京100044; 北京100029; 北京100853; 上海200025; 上海200003; 南京210029; 杭州310003; 广州510120; 广东广州510080;

【摘要】 目的评价比索洛尔/卡维地洛(抗心衰药)治疗充血性心力衰竭的有效性和安全性。方法用多中心随机开放终点盲态法平行对照床试验,选择已接受常规治疗的慢性心力衰竭病人128例(超声LVEF≤40%),随机分为2组,接受比索洛尔或卡维地洛治疗,渐增至最大耐受剂量后,维持4个月。结果治疗后,2组左室射血分数均比用药前明显增加,且左室收缩和舒张期末容量及心胸比例均明显减少,肺瘀血情况和NYHA分级亦明显改善。2组药物不良反应发生率分别为38.16%,46.05%。结论比索洛尔/卡维地洛均可明显改善慢性心衰患者的心功能,耐受性较好。

【Abstract】 Objective To evaluate the effects of bisoprilol /carvedilol in patients with chronic left heart failure. Methods One hundred twenty-eight patients with chronic left heart failure ejection fraction(EF) less or equal to 40% by echocardiography were randomly assigned to either bisoprolol or carvedilol group who received conventional-therapy.β-blockers were increased gradually to the target or the tolerant dosages during 3 months and continued for 4 months.Results Compared with pre-medication, both β blockers produced a sustained and significant improvement in New York Heart Association class,left ventricular(LV) diastolic end diameter and LVEF(all P<0.05) after the treatment of 6 months. There were no significant differences between two groups for the adverse events.Conclusion Both bisoprilol and carvedilol can improve cardiac function in chronic left heart failure patients.

  • 【文献出处】 中国临床药理学杂志 ,The Chinese Journal of Clinical Pharmacology , 编辑部邮箱 ,2006年04期
  • 【分类号】R541.61
  • 【被引频次】22
  • 【下载频次】202
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