【摘要】 目的探讨肌松药对麻醉诱导意识消失期间熵指数的影响。方法30例行腹腔镜胆囊切除术的患者,随机分为2组:试验组给予单次维库溴铵,而对照组给予生理盐水。全麻诱导:2组均接受了目标浓度的丙泊酚输注直到病人意识消失。意识消失后的2分钟,试验组给予单次维库溴铵0.1mg/kg,对照组给予生理盐水。记录脑电双频指数及状态熵和反应熵指数。结果在意识消失时的两组间结果相似。病人意识消失后对照组用药后较意识消失时的脑电双频指数(P<0.002),状态熵(P<0.05),反应熵(P<0.01)均下降。试验组在脑电双频指数(P<0.0001),状态熵(P<0.0001),反应熵(P<0.0001)下降。试验组在双频指数(P<0.05)和反应熵(P<0.01)方面的下降较对照组显著。结论浅麻醉病人给予肌松剂时双频指数和反应熵下降,而状态熵则变化不明显。更多还原

【Abstract】 Objective To investigate the influence of muscle relaxants on entropy values during propofol induced loss of consciousness. Methods Thirty patients ASAI～II ,scheduled for elective laparoscopic surgery, were randomly allocated to received a target-controlled infusion of propofol, titrated until loss of consciousness. Two minutes after loss of consciousness, the study group received a bolus injection of vecuronium, whereas the control group received a placebo(Saline). The following variables were recorded: bispectral index, state entropy, and response entropy. Results Similar values were obtained in both groups at loss of consciousness. Saline administration induced a decrease in bispectral index (P< 0.002), state entropy (P< 0.05), and response entropy (P< 0.01) compared with the values measured at loss of consciousness. Vecuronium administration induced a decrease in bispectral index (P< 0.0001), state entropy (P< 0.0001), and response entropy (P< 0.0001) values. Decreases in bispectral index (P< 0.05) and response entropy (P< 0.01) were larger after vecuronium than placebo injection. Conclusion In lightly anesthetized patients, myorelaxant admin- istration decreases bispectral index and response entropy, but not state entropy values.更多还原