【摘要】 目的研究窒息新生儿血浆β—内啡肽(β-EP)的含量,探讨它与新生儿窒息及窒息后脑损伤的关系。方法采用放射免疫分析法测定37例窒息新生儿及12例健康新生儿血浆β-EP含量,同时行头颅CT检查,并测定脑实质CT值。结果窒息组血浆β-EP含量明显高于对照组,重度窒息组β-EP明显高于轻度窒息组,差异均有显著意义。CT值比较结果示:窒息组CT值明显低于对照组,重度窒息组明显低于轻度窒息组,差异均有显著意义;轻、重度窒息组血浆β-EP水平与脑实质CT值呈显著负相关(γ分别为0.696、0.809,P<0.01),但对照组血浆β-EP水平与脑实质CT值相关分析,无统计学意义。结论血浆β-EP含量及CT值与窒息程度密切相关,窒息越重,血浆β-EP含量越高,CT值越低。血浆β-EP可作为观察新生儿窒息程度和窒息后脑损伤的指标。更多还原

【Abstract】 Objective to study plasma β-Endorphin(β-EP) level in neonatal asphyxia.To explore its relation- ship with post-asphyxia brain damage.Methods plasma β-EP levels was measured in 37 asphyxialed and 12 normal term neonates by radio-immunoassay.The cerebral CT value and its value were observed .Results plasma β-EP levels was much higher in asphyxiated neonates than that of control group.The severe group levels was much higher than the mild one.The difference was higher significant.The CT values asphyxia group was obviously lover than that of the control group .The difference was significant.There were a positive correlation between the mild.The severe asphyxia. the cerebral CT value (r=-0.696,-0.809,P<0.01).But,there was no closely related with the degree of asphyxia,the more severe the asphyxia,the higher the plasma levels of β-EP ,and the lower the CT value .The plasmaβ-Ep may be used as the markers in evaluating. The degrees of neonate asphyxia and post-asphyxia brain damage.更多还原