【摘要】 目的研究胃癌与大肠癌患者P53蛋白与P-糖蛋白的表达异同与临床意义。方法应用免疫组织化学方法对49例胃癌患者与50例大肠癌患者P53蛋白与P-糖蛋白表达进行检测。结果发现在胃肠癌患者中,P53蛋白阳性表达者占41%,P-糖蛋白阳性表达者占63%,两者的表达有相互关联,在大肠癌患者中P53蛋白阳性表达者占52%,P-糖蛋白阳性表达者占50%,两者表达亦正相关。而胃癌患者与大肠癌患者在P53蛋白与P-糖蛋白表达结果分析相类似。结论结果显示在胃癌和大肠癌患者中P53蛋白表达与患者的多药耐药相关。更多还原

【Abstract】 Objective To study the expression of P-glycoprotein and P53 protein and its relationship in gastric carcinoma and colorectal carcinoma. Methods Forty-nine cases with gastric carcinoma and Fifty case colorectal carcinoma were subjected to inmunohistochemical to observe the expression of P-glycoprotein and P53 protein and its relationship. Results In gastric carcinomas the positive expression of P-glycoprotein was found in 63%and the positive expression of P53 protein was found in 41%. Both expression was interrelated. In colorectal, carcinomas the positive expression of P- glycoprotein was found in 50% and positive expression of P53 protein was found in 52% Both expression was interrelation. Both expression of p-glycoprotein of gastric and colorectal carcinomas was similar. Conclusion The result shows that P53 protein correlated with the multidrug resistance in gastric and colorectal carcinoma.更多还原