【摘要】 目的探讨硫酸钙/骨基质明胶生物活性复合人工骨的制备方法及其理化性能。方法分别制备硫酸钙、骨基质明胶颗粒,按1：1、2：1、3：1、1：0不同质量比例制备复合人工骨。经扫描电镜观察、生物力学测试及体外降解试验,研究不同配比复合人工骨的结构特征、力学强度及降解速率。结果硫酸钙与骨基质明胶呈均匀混合分布,材料内见较多孔径为100～500μm的微孔结构,孔隙间相互交通,随着骨粒含量的增加,孔径逐渐增大。质量比为1：1、2：1、3：1、1：0的复合人工骨的抗压强度分别为(3．53±0．62)、(6．74±0．78)、(13．60±1．01)、(39．85±2．33)MPa,100%体外降解时间分别为8、10、12、12周。结论硫酸钙/骨基质明胶复合人工骨具有利于新骨长入的微孔结构,随着骨粒含量的增高,材料的力学强度逐渐减低,降解时间加快,不同配比的复合材料可适用于不同的植骨需要。更多还原

【Abstract】 Objective To investigate the method for preparation of bioaetive composite bone substitute comprising calcium suffate (CS) and bone matrix gelatin (BMG) and analyze its physical and chemical properties.Methods Bioactive composite bone substitute was pre- pared with different mass ratios of CS to BMG (1:1,2:1,3:1 and 1:0).The structural characteristics,the mechanical strength and the degradation rate were evaluated with the scanning electron microscopy,the compressive strength measurement and the degrada- tion experiment in vitro.Results The particles of CS and BMG were distributed uniformly.In the compound,there were many cellu- lar structures ranging from 100 to 500μm in which the pores were connected each other.With the increase of the content of bone parti- cles,the aperture was increased gradually.The compressive strength was 3.53±0.62,6.74±0.78,13.60±1.01 and 39.85±2.33 MPa respectively for different mass ratios of CS to BMG (1:1,2:1,3:1 and 1:0) and the time for full degradation was 8,10, 12 and 12 weeks respectively.Conclusion The biological composite bone substitute comprising CS and BMG has cellular structure that is favorable for the new bone growing into the compound.With the increase of the content of bone particles in the compound,the me- chanical strength is decreased gradually as well as the degradation time.The composite materials with different proportioning may be ap- plicable for bone grafting with different requirements.更多还原