【摘要】 目的比较不同剂量吲达帕胺(Ind)和替米沙坦(Tel)联用对自发性高血压大鼠(SHR)的降压作用及对心功能的影响。方法40只SHR随机分为5组:①空白对照组;②低-低剂量组:Ind 0.06 mg/kg.d-1,Tel 3.57 mg/kg.d-1;③低-高剂量组:Ind 0.06 mg/kg.d-1,Tel 7.14 mg/kg.d-1;④高-低剂量组:Ind 0.12 mg/kg.d-1,Tel 3.57 mg/kg.d-1;⑤高剂量单用组:Tel 7.14 mg/kg.d-1,灌胃给药,连续给药4周,尾袖法测收缩压,Langendorff灌流心脏测量心功能。结果低-低剂量联用组,能有效降低SHR的收缩压,降低左室舒张末期压,减少左室重与体质量之比。结论小剂量联合应用吲达帕胺和替米沙坦对SHR的降压作用及心功能的改善与大剂量单用替米沙坦的疗效一致。更多还原

【Abstract】 Objective The purpose of this research is to study on the effect of SBP reduction and cardiac function of treatment with different dose combination of Indapamide and Telmisartan on SHR(spontaneously hypertensive rat).Methods 40 SHR were randomly divided into 5 groups,①An untreated group ②Low-low dose combination: Ind 0.06 mg/kg and Tel 3.57 mg/kg per day ③Low-high dose combination: Ind 0.06 mg/kg and Tel 7.14 mg/kg per day ④High-low dose combination: Ind 0.12 mg/kg and Tel 3.57 mg/kg per day ⑤High dose of telmisartan: Tel 7.14 mg/kg per day.All SHR had been treated with drugs by gavage method for successive 4 weeks.The tail arterial SBP of rat was measured once a week during the period of trial.Cardiac function was assessed by isolated langendorff heart perfusion.Results All of 4 treatment groups showed significant decrease in SBP(P<0.01).LV systolic function was improved in Ind-L/Tel-L group compared with control groups(P<0.05),and the ratio of heart weight decreased significantly by 21%(P<0.05) in Ind-L/Tel-L group.Conclusions Combination of low dose of indapamide and telmisartan as well as high dose telmisartan alone decrease the SBP of SHR significantly.更多还原