【摘要】 Novozym e-435催化10-羟基癸酸进行自缩聚反应得到线性聚酯,端基分别是羟基(—OH)和羧基(—COOH),在三乙胺催化下,分别用α-溴代丙酰溴和三甲基氯硅烷(TMSCL)进行端基官能化生成一个单官能度的大分子引发剂,在CuC l/2,2′-联吡啶(bpy)催化体系中,引发甲基丙烯酸环氧丙酯(GMA)的原子转移自由基反应(ATRP),得到聚(10-羟基癸酸酯)/聚甲基丙烯酸环氧丙酯(PHDA-b-PGMA)AB型两亲性嵌段共聚物,其结构及分子量(分布)通过核磁共振和凝胶渗透色谱(GPC)确证.此AB型两亲性嵌段共聚物在水溶液中能自组装形成纳米粒子,用原子力显微镜(AFM)观察粒子的形状和大小.更多还原

【Abstract】 The diblock copolymers poly(10-hydroxydecanoic acid)-block poly(glycidyl methacrylate)((PHDA-b-PGMA)) were synthesized by combining enzymatic condensation polymerization of 10-hydroxydecanoic acid(HDA) and atom transfer radical polymerization(ATRP) of glycidyl methacrylate(GMA).PHDA was firstly obtained via enzymatic condensation polymerization catalyzed by Novozyme-435.Subsequently one end of PHDA chains was modified by reaction with α-bromopropionyl bromide and the other was protected by chlorotrimethylsilane(TMSCL),respectively,the resulting monofunctional macroinitiator was used in the(ATRP) of GMA using CuCl/2,2′-bipyridine(bpy) as the catalyst system to afford the diblock copolymers including biodegradable PHDA blocks and well-defined PGMA blocks.Polymer nanospheres were prepared by the self-assembly behaviors of the amphiphilic diblock copolymers PHDA-b-PGMA in aqueous solvent.更多还原