【摘要】 设计合成了两个系列20个含α-氨基酸的新型有机锗化合物,对化合物进行了波谱表征,用X射线衍射测定了化合物Ph3GeCH(Ph)CH2CONHCH(CH2COOC2H5)COOC2H5的晶体结构.抗肿瘤实验结果表明,这两个系列的化合物有一定的抗KB,HCT-8和Bel-7402活性.更多还原

【Abstract】 In order to search new organogermanium antitumor drugs with an activity and low toxicity,20 new organogermanium compounds were designed and synthesized by attaching α-amino acid to organogermanium moieties.Their structures were confirmed by IR,（）¹H NMR and elemental analysis.The crystal structure of(Ph₃GeCH（Ph）CH₂CONHCH(CH₂COOC₂H₅)COOC₂H₅) were determined by X-ray diffraction.Three human neoplastic cell lines（KB,HCT-8 and Bel-7402） were used to screen these compounds.The results indicate that some compounds at 5 μmol/L show a weak in vitro antitumor activity.更多还原