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人参皂苷Rb1在大鼠体内的药物代谢研究

In Vivo Rat Metabolism Studies of Ginsenoside-Rb1

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【作者】 杨柳许舜军曾星巫志峰邓远辉刘奕明邓时贵欧润妹

【Author】 YANG Liu~(1),XU Shun-Jun~(2),ZENG Xing~(1*),WU Zhi-Feng~(1), DENG Yuan-Hui~(1),LIU Yi-Ming~(1),DENG Shi-Gui~(1),OU Run-Mei~(1) (1.Guangdong Provincial Hospital of TCM,Guangzhou 510120,China; 2.Laboratory of Pharmacognosy,China Pharmaceutical University,Nanjing 210038,China)

【机构】 广州中医药大学附属广东省中医院中国药科大学生药研究室广州中医药大学附属广东省中医院 广州510120南京210038广州510120

【Abstract】 The major metabolites of ginsenoside-Rb1 in rats urine were described.Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb1 to four rats,respectively.The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites.Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra.Its main metabolic pathways and possible structures are analyzed in detail.

【基金】 国家“八六三”计划(批准号:2002AA2Z341B)资助
  • 【文献出处】 高等学校化学学报 ,Chemical Journal of Chinese Universities , 编辑部邮箱 ,2006年06期
  • 【分类号】R285
  • 【被引频次】38
  • 【下载频次】1370
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