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人参皂苷Rb₁在大鼠体内的药物代谢研究

In Vivo Rat Metabolism Studies of Ginsenoside-Rb₁

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【Author】 YANG Liu~(1),XU Shun-Jun~(2),ZENG Xing~(1*),WU Zhi-Feng~(1), DENG Yuan-Hui~(1),LIU Yi-Ming~(1),DENG Shi-Gui~(1),OU Run-Mei~(1) (1.Guangdong Provincial Hospital of TCM,Guangzhou 510120,China; 2.Laboratory of Pharmacognosy,China Pharmaceutical University,Nanjing 210038,China)

【机构】广州中医药大学附属广东省中医院；中国药科大学生药研究室；广州中医药大学附属广东省中医院广州510120；南京210038；广州510120；

【Abstract】 The major metabolites of ginsenoside-Rb₁ in rats urine were described.Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb₁ to four rats,respectively.The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites.Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra.Its main metabolic pathways and possible structures are analyzed in detail.更多还原