【Abstract】 Three natural deoxynucleosides were synthesized with a high stereoselectivity and good or excellent yield.In the preparation of 2′-deoxy-β-D-adenosine, glycosidations between 1-chloro-2-deoxy-3,5-di-O-(p-chlorobenzyl)-α-D-erythro-pentofuranose and silylated adenine as well as adenine sodium salt were systematically studied.A simple synthesis route to prepare 2′-deoxy-β-D-adenosine without chromatography was developed,making 2-deoxy-β-D-adenosine readily accessible in an industrial scale.High efficient synthesis of 2′-deoxy-β-D-cytidine and 2′-deoxyβ-D-thymidine were also achieved without chromatography by glycosidations between 1-chloro-2-deoxy-3,5-di-O-(p-chlorobenzyl)-α-D-erythro-pentofuranose and silylated bases via the similar procedure.更多还原