【摘要】 目的探讨应用药物预防激素性股骨头坏死。方法30只兔随机分为3组,对照组同期肌注生理盐水;激素组给予糖皮质激素肌注;治疗组给予以上剂量糖皮质激素的同时每日使用血塞通、脂必妥和阿仑膦酸钠,观察股骨头组织结构和血流量。结果激素组股骨头骨小梁稀疏、变细,脂肪细胞增大,电镜下骨细胞体积缩小,核固缩,染色质边聚,空骨陷窝明显增多为(24.8±7.62)%,股骨头血流量为(0.197±0.083)ml·min-1·g-1;治疗组未发现骨小梁形态变化,空骨陷窝为(15.2±5.47)%,股骨头血流量为(0.262±0.092)ml·min-1·g-1。治疗组血流量较激素组多,两组比较差异有统计学意义(P<0.05);治疗组空骨陷窝与激素组差异有统计学意义(P<0.01)。结论在长程使用类固醇激素同时应用血塞通、脂必妥和阿仑膦酸钠可提高股骨头血流量,改善骨组织结构,预防或减缓激素性股骨头坏死。更多还原

【Abstract】 Objective To explore protective action of drugs on experimental hormonal necrosis of femoral head. Methods Thirty rabbits were divided randomly into 3 groups: group A, group B, and group C. Rabbits in group A were injected with normal saline; rabbits in group B were treated with glucocorticoid; rabbits in group C were treated with glucocorticoid as that in group B, and meanwhile, orally received the Panax notoginseng saponins, Zhibituo and Alenduonate for 8 weeks. Histopathological structure and blood flow of femoral head were observed. Results Compared with the C group, the trabecula of femoral head of the B group changed to thinner and more sparse, the bone marrow cavity with edema and large fatty cells were also observed. Under electron microscope, B group showed a great deal of necrotic osteocytes with pyknotic nucleus. The empty bone lacune in the B group (24.8±7.62)% increased with the C group (15.2±5.47)%. The bone blood flow in the C group, (0.262±0.092) ml·min-1·g-1, increased compared with the B group, (0.197±0.083) ml·min-1·g-1. Conclusion The Zhibituo, Panax notoginseng saponins and Alenduonate may prevent steroid-induced necrosis of femoral head更多还原