【摘要】 目的探讨谷胱甘肽S转移酶M1基因多态性与直肠癌的关系。方法以聚合酶链反应方法,分析了56个直肠癌病人和性别、年龄配对的143个正常对照的谷胱甘肽S转移酶M1基因型及其对直肠癌的相关性。结果GSTM1基因缺失频率在病例组和对照组之间无有显著差异。结论GSTM1基因缺失可能不是结直肠癌发生的易感基因型。更多还原

【Abstract】 ObjectiveTo explore the relationship between genetic polymorphisms in glutathione-S-transferase M1 (GSTM1) and adenocarcinoma of the colorectal. MethodsGenomic DNA was isolated from the peripheral lymphocytes of 56 patients with colorectal cancer and 143 age-sex matched control subjects. Polymerase chain reaction was used to examine the polymorphisms of GSTM1 genes and the relation between these genotypes and risk of AGC was analyzed. ResultsThe frequency of the null GSTM1 genotype in patients showed a no statistically significant increase as compared to that in the controls. ConclusionGSTM1 null genotype may not be a genetic susceptibility factor for colorectal cancer.更多还原