【摘要】 目的观察还原型谷胱甘肽(GSH)联合二甲双胍对非酒精性脂肪肝的治疗作用。方法随机将60例非酒精性脂肪肝患者分成两组,治疗组30例给予还原型谷胱甘肽联合二甲双胍治疗,对照组30例服用水飞蓟素及维生素C片治疗,疗程为4月~6月。治疗前后测定患者血清ALT、AST、γ-GT水平、血脂水平(TG、TC、LDL-C及HDL-C)、胰岛素抵抗指数(IRI)及肝/脾CT比值并作统计学处理,同时观察治疗过程中出现的不良反应。结果治疗组患者治疗后ALT、AST、γ-GT均明显降低,差异显著,对照组治疗后ALT有所下降,而AST、γ-GT较治疗前无明显改善;治疗组患者治疗后各项血脂水平均显著改善,而对照组变化不明显(P>0.05);治疗后治疗组胰岛素抵抗指数明显下降(P<0.05);而对照组无明显改变(P>0.05);同时治疗组治疗后肝/脾CT比值显著提高(P<0.01)。用药期间两组患者均未出现显著的不良反应。结论还原型谷胱甘肽联合二甲双胍对非酒精性脂肪肝有显著疗效且用药安全。更多还原

【Abstract】 Objective To assess the therapeutic effect of reduced glutathione combined with methormin on patients with non-alcoholic fatty liver disease.Methods 60 patients with non-alcoholic fatty liver disease were randomly divided into two groups and the patients in treatment group were treated with reduced glutathione combined with metformin(n=30) , while in control group treated with silymarin combined with vitamin C (n=30) for consecutive 4～6 months. Results The levels of serum ALT,AST,γ-GT in treatment group were all abviously reduced at the end point compared with the baseline. The levels of serum ALT in control group was reduced, but the levels of serum ALT,AST, γ-GT were no obriously changed; the abnormity of TG,TC,LDL-C and HDL-C were all markedly ameliorated in treatment group while no obvious change occurred in control group after treatment; the level of IRI in treatmant group was significantly decreased at the end point compared with the baseline(P<0.05),while the change wasn′t obvious in control group(P>0.05);meanwhile, liver/spleen CT ratio in treatment group were obviously increased after treatment(P<0.01), and no severe side-effects occurred during the experiment.Conclusion Reduced glutathione combined with methormin is an effective and safe remedy for treatment of non-alcoholic fatty liver discase.更多还原