【摘要】 研究重离子辐照小鼠头部对脾脏细胞周期分布的影响,为重离子放射治疗癌症和太空防护提供基础数据。80MeV/u能量的12C6+对BALB/c小鼠头部给以0、0.5、1、2、4、10Gy的照射,用流式细胞仪测脾脏细胞周期分布。重离子辐照后36h,小鼠脾脏细胞S期细胞随着辐照剂量的增加显著减少(p<0.05);0.5Gy组、4Gy组和10Gy组出现G1/G0期阻滞明显阻滞(p<0.05),1Gy组和2Gy组无显著变化(p﹥0.05);0.5Gy组G2/M期细胞显著减少(p<0.01),其它剂量组明显阻滞(p<0.05)。重离子辐照小鼠头部对小鼠脾脏细胞周期分布有明显影响。更多还原

【Abstract】 After whole head irradiation (WHI) of mice with 12 C 6+ ions (80 MeV /u), changes of cycle distribu-tion of spleen cells were studied, in an attempt to provide basic data for heavy ion radiotherapy and space radiation protection. The heads of the BALB/c mice were irradiated with 0, 0.5, 1, 2, 4 or 10 Gy by the 12 C 6+ ions. The cell cy-cle distribution was analyzed by flow cytometry. Thirty-six hours after the irradiation, the S phase cells were reduced significantly (p<0.05) with increasing doses. The 0.5 Gy, 4 Gy and 10 Gy WHI groups showed evident arrest in G1 / G0 phase (p<0.05), but the 1 Gy and 2 Gy WHI groups had no significant arrest (p>0.05). G2 / M phase of the 0.5 Gy WHI group was reduced markedly (p<0.01), while the other groups showed obvious arrest (p<0.05). After WHI of mice with the heavy ions, spleen cell cycle distribution of mice changed significantly.更多还原