【摘要】 建立了一种简捷的方法来计算细胞接受重离子照射后发生染色体断裂的产额。L02细胞接受碳离子照射后染色体断裂的产额,并应用早熟染色体凝集技术获得该细胞在经重离子照射后的染色体断裂产额的实验值。通过理论计算,得到了12C6+照射人正常肝细胞L02后不同吸收剂量点的染色体断裂产额,与应用早熟染色体凝集技术实验中实际获得的染色体断裂产额基本吻合。说明,细胞在接受重离子束照射的初始阶段可能是物质相互作用的物理过程,细胞内的生物机能对这一过程的干预尚未启动。提示重离子的高相对生物学效应与重离子的物理特性密切相关。更多还原

【Abstract】 An easy method was established for computing chromosome breaks in cells exposed to heavily charged particles. The cell chromosome break value by 12C+6 ions was theoretically calculated, and was tested with experimental data of chromosome breaks by using a premature chromosome condensation technique. The theoretical chromosome break value agreed well with the experimental data. The higher relative biological effectiveness of the heavy ions was clusely correlated to its physical characteristics. In addition, the chromosome break value can be pre-dicted off line.更多还原