【摘要】 目的:研究动态增强MR成像(DCE-MRI)技术与血液病骨髓细胞构成的相关性。方法:25例确诊的恶性血液病患者通过DCE-MRI及髂嵴穿刺活检进行对照分析,测定骨髓灌注的最大强化率(PER)、最大强化斜率值(Slopemax)、峰值时间(TTP)、平均时间(MT)以及骨髓活检分析细胞构成(Cellularity)。结果:骨髓细胞构成与动态增强的PER呈正相关(r=0.564)、与其Slopemax也呈正相关(r=0.478),统计差异有显著性意义(P<0.05)。骨髓细胞构成与TTP呈负相关(r=-0.305),与MT呈正相关(r=0.186),但统计学上差异无显著性意义(P>0.05)。结论:动态增强MR成像能够监测血液病骨髓细胞构成的变化。更多还原

【Abstract】 Objective:To evaluate the bone marrow states with the variable values of dynamic contrast-enhanced MR （DCE-MRI）.Methods:DCE-MRI results were obtained from 25 patients with proven or known haematological malignancies.Time-signal intensity curves （TIC） analyzed was generated from the region of the iliac crest corresponding to the planned biopsy site.Enhancement characteristics were analysed,including peak enhance ratio （PER）,maximum slope （Slope max）,time to peak （TTP） and mean time （MT）.The parameters of the marrow histology included cellularity.Results:PER and Slope max values were significantly higher for hypercellularity group than for normalcellularity and hypocellularity group （P<0.005）.A significant positive correlation was found between PER and cellularity,Slope max and cellularity.A negative correlation was found between TTP and cellularity,but mean TTP and MT values for hyper-,hypo-,and normal cellularity groups did not differ significantly.Conclusion:Our preliminary findings suggest that the bone marrow cellularity in patients with haematological malignancies cannot be verified using T₂WI with fat saturated and the signal uniformity,but can be verified using the variable values from the time-intensity curve analysis with DCE-MR imaging.更多还原