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牙周病患者血清IL-1β和TNF-α检测的临床意义

Clinical Significance of Determination of Serum IL-1β,TNF-α Levels in Patients with Periodontitis

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【作者】 魏东章晓蕾

【Author】 Wei Dong,Zhang XiaoleiChangzhou Traditional Chinese Medical Hospital,Changzhou,Jiangsu(213003)

【机构】 江苏省常州市中医院口腔科江苏省常州市中医院口腔科 213003213003

【摘要】 目的探讨了牙周病患者血清白介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)含量的变化及意义。方法应用放免法检测了42例牙周病患者血清中IL-1β和TNF-α水平的变化,并以35名正常健康人作比较。结果牙周病患者血清IL-1β和TNF-α水平非常显著地高于正常人组(P<0.01),且两者呈明显正相关(r=0.4182,P<0.01)。结论检测血清中IL-1β和TNF-α水平与牙周病的发病机理密切相关。

【Abstract】 Objective To investigate the changes of serum IL-1β and TNF-α levels in patients with periodontitis.Methods Serum IL-1β and TNF-α levels were measured with RIA in 42 patients with periodontitis and 35 controls.Results Serum IL-1β and TNF-α levels in the patients were significantly higher than those in controls(P<0.01).Serum IL-1β level was positively correlated with TNF-α level(r=0.4182,P<0.01).Conclusion Increase of serum IL-1β and TNF-α levels in patients with periodontitis was closely related to the pathogenesis of the disease.

  • 【文献出处】 放射免疫学杂志 ,Journal of Radioimmunology , 编辑部邮箱 ,2006年06期
  • 【分类号】R781.4
  • 【被引频次】15
  • 【下载频次】146
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