【摘要】 目的:探讨肌钙蛋白T(cTnT)、IL-8和TNF-α在病毒性心肌炎(VMC)诊断及预后中的价值。方法:对86例VMC患者进行入院后1个月、6个月以内及6个月以上cTnT、IL-8和TNF-α的动态检测,并与正常对照组30例的检测结果进行比较。结果:VMC组急性期cTnT、IL-8和TNF-α阳性率(47.67%、65.12%和74.41%)较6个月以内组(34.32%、46.23%和41.79%)、6个月以上组(15.79%、21.05%和10.52%)及正常对照组(0%)显著升高(P<0.01);病程6个月以内组cTnT、IL-8和TNF-α阳性率较6个月以上组升高(P<0.05)。cTnT阳性者急性期的治愈率(12.2%,5/41)显著低于阴性者(48.8%,21/45)(P<0.005);cT-nT阳性者6个月以内组的治愈率(63.4%,26/41)显著低于阴性者(91.1%,41/45)(P<0.005)。结论:cTnT、IL-8和TNF-α是有助于及早诊断VMC即敏感又特异的指标,在VMC预后判断中具有重要意义。更多还原

【Abstract】 Objective To investigate the value of determination of blood cardiac troponin T(cTnT),IL-8 and TNF-α conttents for the diagnosis and prognosis assessment in patients with viral myocarditis(VMC).Methods Plasma cTnT(with immuno-infiltration method) and serum IL-8,TNF(with ELISA) contents were measured in 86 patients with VMC at different stages(1 months,<6 months,>6 months),and 30 controls.Results The positive rates of blood cTnT,IL-8 and TNF-α in acute VMC patients were significantly higher than those in patients with history less than 6 months as well as with history more than 6 months and the controls group(P<0.01).The positive rates of cTnT,IL-8 and TNF-α in cases with of history less than 6 months were significantly higher than cases with of history more than 6 months(P>0.05).The cure rate in patients with positive cTnT was significantly lower than that in patients with negative cTnT both at 1 months and 6 months(P<0.005).Conclusion Blood cTnT,IL-8 and TNF-α are sensitive and specific predictors for diagnosis and prognosis assessment in patients with VMC.更多还原