【摘要】 目的:探讨了冠心病患者血清IL-6、IL-10、IL-18和TNF-α检测的临床意义。方法:分别应用放射免疫分析和酶联免疫法对71例冠心病患者进行了血清IL-6、IL-10、IL-18和TNF-α水平检测(其中稳定性心绞痛35例、不稳定心绞痛21例、急性心肌梗死15例),并与35名正常健康人作比较。结果:冠心病患者血清IL-6、IL-10、IL-18和TNF-α水平均非常显著地高于正常人组(P<0.01),急性心肌梗死组和不稳定心绞痛组又高于稳定型心绞痛组(P<0.05)。结论:检测冠心病患者血清中IL-6、IL-10、IL-18和TNF-α水平对疾病的预后观察具有重要的临床价值。更多还原

【Abstract】 Objective To explore the significance of changes of serum IL-6,IL-10,IL-18 and TNF-α levels in patients with coronary heart disease(CHD).Methods Serum levels of IL-6 TNF-α(with RIA) IL-10,IL-18,levels(with ELA) were measured in 71 patients with CHD(35 SAP,21 UAP,15 AMI) and 35 controls.Results Serum levels of IL-6,IL-10,IL-18 and TNF-α in patients with coronary heart disease were significantly higher than those in the controls(P<0.01),Among the CHD patients,the levels of IL-6,IL-10,IL-18 and TNF-α in AMI and UAP groups were significantly higher than those in SAP Group(P<0.05).Conclusion Levels of serum pro-inflammatory cytokines IL-6,IL-10,IL-18 and TNF-α levels increased significantly in patients with coronary heart disease especially in those advanced cases.更多还原