【摘要】 目的:探讨了冠心病患者血清超敏C反应蛋白(hs-CRP)和巨噬细胞集落刺激因子(M-CSF)检测的临床意义。方法:应用免疫比浊法测定hs-CRP、放免法测定M-CSF,对71例冠心病患者进行了测定,其中稳定型心绞痛35例,不稳定型心绞痛21例,急性心肌梗死15例,进行了血清hs-CRP和M-CSF水平的测定,并以35名正常健康人作比较。结果:冠心病患者血清hs-CRP和M-CSF水平明显地高于正常人组(P<0.01),急性心肌梗死组和不稳定型心绞痛组又高于稳定型心绞痛组(P<0.05),冠心病组血清hs-CRP、M-CSF水平与冠状动脉狭窄程度无明显的相关性(P>0.05)。结论:血清hs-CRP、M-CSF水平的变化与冠心病的发生、发展有关,但与冠状动脉狭窄程度无关。更多还原

【Abstract】 Objective To investigate the significance of determination of serum contents,of hs-CRP and M-CSF in patients with coronary heart disease(CHD).Methods Serum hs-CRP contents were determined with immuno-turbidity and M-CSF contents were determined with RIA in 71 patients with CHD(35 SAP,21 UAP,15 AMI) and 35 controls.Results Serum levels of hs-CRP and M-CSF in CAD patients were significantly higher than those in controls(P<0.01).Among the CHD patients,the levels of hs-CRP and M-CSF in AMI and UAP groups were significantly higher than those in SAP group(P<0.05).There was no relationship between degree of stenosis of coronary artery and serum levels of hs-CRP and M-CSF(P>0.05).Conclusion The serum levels of hs-CRP and M-CSF were related to development of CAD,but no relationship existed between the levels and coronary artery calibers.更多还原