【摘要】 目的:探讨自身抗体在系统性红斑狼疮(SLE)中的意义。方法:采用放射免疫分析检测50例SLE患者血清中的抗双链DNA(dsDNA)抗体,采用德国IMTEC公司抗核抗体谱线性印迹法检测抗核小体抗体(An-uA)、抗组蛋白抗体(AHA)、抗SmD1等其他自身抗体。结果:抗SmD1阳性率最高(82%),其次是抗Ro60KD抗体(80%)和AunA(72%);抗dsDNA、AHA、抗U1-RNP、抗Ro52KD、抗SSB的阳性率分别为44%、32%、58%、48%、24%。其他三种自身抗体阳性率很低。结论:SLE患者血清中可出现大量的自身抗体,同时检测多种自身抗体能提高对SLE的鉴别诊断。更多还原

【Abstract】 Objective To explore the roles played by autoantibodies in systemic lupus erythematosus.Methods Serum anti-dsDNA antibody(with RIA) and serum anti-nucleosome antibody(AnuA),AHA,anti SmD1-,anti Ro60UD-,anti U1-RNP-,anti-Ro52KD,anti-SSB-antibodies(with anti-nucleo antibodies linear spectrum blotting method) were detected in 50 patients with clinically proven systemic lupus erythematosus.Results The positive rate with anti-SmD1 antibody was highest(82%),followed by anti-Ro60KD antibody(80%) and AnuA(72%).Positive rate with anti dsDNA-,AHA,anti-U1-RNP-,anti-Ro52KD and anti SSB-antibodies was 44%,32%,58%,48% and 24% respectively.Positive rate with anti-SC1-70,ACA and Jo-1 antibodies was extremely low(below 10%).Conclusion Multiple auto-antibodies were present in serum of patients with systemic lupus erythematosus and combined detection of them would improve the diagnostic sensitivity.更多还原