【摘要】 目的:探讨垂体腺瘤患者术前、术后血清中甲状腺激素的变化,分析其临床意义。方法:从垂体肿瘤手术病人中,筛选出病理诊断为垂体腺瘤患者纳入分析。50例垂体腺瘤切除术患者均做血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、人血清3,3,’5’-三碘甲腺原氨酸(rT3)的水平测定。结果:垂体腺瘤病人术前FT4、rT3明显低于正常人,FT3、TSH与正常人无显著性差异,和术前比较,垂体腺瘤切除术后FT3明显下降,rT3明显回升,FT4、TSH变化不明显。结论:术前、术后测量甲状腺激素水平有助于监测甲状腺功能恢复情况,以协助判断手术效果。更多还原

【Abstract】 Objective To investigate the clinical significance of determination of changes of serum thyroid hormones levels after operation in patients with pituitary ademoma.Methods Serum FT₃、FT₄、TSH（with CLIA） and rT₃（with RIA） levels were determined in 50 patients with pituitary adenoma both before and one week after operation as well as in 86 controls.Results The serum FT₄ and rT₃ levels in the patients before operation were significantly lower than those in controls,but the FT₃ and TSH levels were not significantly different.Post-operatively,FT₃ levels dropped markedly,but rT₃ levels rose markedly while the FT₄,TSH levels were not greatly changed.Conclusion There were mild thyroid dysfunction in patients with apparently nonfunctioning pituitary adenoma.更多还原