【摘要】 目的:探讨慢性阻塞性肺病(COPD)患者血清IGF-Ⅱ水平的变化及其临床意义。方法:采用放射免疫分析测定60例COPD患者和30例非COPD患者的血清IGF-Ⅱ水平,并进行对照统计分析。结果:COPD组血清IGF-Ⅱ水平显著高于对照组(0.65±0.22μg/L vs 0.51±0.18μg/L;t=3.015;P<0.01),Ⅰ、Ⅱ、Ⅲ期COPD患者间IGF-Ⅱ水平无显著性差异(F=0.287,P>0.05),住院死亡组血清IGF-Ⅱ水平显著高于好转出院组(t=2.727,P<0.05)。结论:COPD患者血清IGF-Ⅱ显著升高,住院死亡组升高更明显。更多还原

【Abstract】 Objective To explore the clinical significance of the changes of serum insulinlike growth factor Ⅱ(IGF-Ⅱ) levels in patients with chronic obstruive pulmonary diseases(COPD).Methods The serum IGF-Ⅱ levels was determined with radioimmunoassay in 60 patients with COPD and 30 controls.Results The serum IGF-Ⅱ levels in patients with COPD were significantly higher than those in controls(0.65±0.22μg/L vs 0.51±0.18μg/L,P<0.01).There were no significant differences among the levels in patients of different stages(stages Ⅰ,Ⅱ,Ⅲ).Levels of IGF-Ⅱ were significantly higher in patients succumbed to the disease than those in patients recoverd(P<0.05).Conclusion Serum IGF-Ⅱ levels were significantly increased in patients with COPD,especially in those succumbed.更多还原