【摘要】 目的:探讨慢性乙型肝炎患者血清TGF-β1、IL-8和IL-18水平的变化。方法:应用放免法和酶免法对42例慢性乙型肝炎患者进行了血清TGF-β1、IL-8和IL-18水平检测,并与35名正常人作比较。结果:慢性乙型肝炎组患者血清TGF-β1、IL-8和IL-18水平均非常显著地高于正常人组(P<0.01),且IL-8、IL-18与TGF-β1呈明显的正相关(r=0.6718,0.6321,P<0.01)。结论:检测慢性乙型肝炎患者血清TGF-β1、IL-8和IL-18水平对疾病的诊断和治疗是一个有用的临床指标。更多还原

【Abstract】 Objective To explore clinical significance of the changes of serum TGF-β₁,IL-8 and IL-18 levels in patients with chronic hepatitis B.Methods Serum IL-8 levels were detected with RIA and TGF-β₁,IL-18 levels were detected with ELISA in 42 patients with chronic hepatitis B and 35 controls.Results The levels of serum TGF-β₁,IL-8 and IL-18 were significantly higher in the patients than those in controls（P<0.01）.Serum IL-8,IL-18 levels were positively correlated with TGF-β₁ levels（r=0.6718,0.6321,P<0.01）.Conclusion Detection of serum TGF-β₁,IL-8 and IL-18 levels might be of prognostic importance in patients with chronic hepatitis B as high levels of these cytokines might favor malignant changes.更多还原