【摘要】 目的:通过对134例慢性肾功能衰竭患者血清瘦素(leptin)水平的检测,探讨慢性肾功能衰竭与瘦素的关系及发生机理。方法:患者134例(男73,女61),年龄(36~80)岁。均经确诊。入院后第2d抽取空腹静脉血,用放射免疫分析(R IA)检测血清瘦素,同时检测40例健康成人作对照组。结果:慢性肾功能衰竭组瘦素水平显著高于对照组(t=2.39,P<0.01)。慢性肾功能衰竭早期、肾衰竭期、尿毒症期患者瘦素无差异。结论:慢性肾功能衰竭患者存在高瘦素血症和瘦素抵抗,瘦素参与了能量平衡的调节,瘦素水平增高是慢性肾功能衰竭的危险标志物。其发生机理有待深入研究。更多还原

【Abstract】 Objective To explore the relationship between chronic renal failure and serum leptin levels in patients with chronic renal failure.Methods Serum leptin levels(with RIA) were determined in 134 patients(male,73,fenmle 61) with chronic renal failure and 40 controls.Results The serum levels of leptin in the chronic renal failure group were significantly higher than those in the controls(t=2.39,P<0.01).There were no significant differences among the leptin levels in patients with different stages of renal failure.Conclusion There were hyper-leptinemia and leptin resistance in patients with chronic renal failure.The increase of leptin levels is thought to be harmful in patients with chronic renal failure,however,the precise mechanism remains to be studied further.更多还原