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儿童5种多基因遗传病与结合珠蛋白遗传多态的关系

Relationship between Genetic Polymorphism of Haptoglobin and Five Polygenetic Inherited Diseases in Children

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【作者】 邹起练陈元仲林颖林祥泉

【Author】 Zou Qilian~(1),Chen Yuanzhong~(2),Lin Ying~(1),Lin Xiangquan~(3)1.Division of Cell Biology and Genetics,Fujian Medical University,Fuzhou 350004,China2.Fujian Institute of Hematology,The Affiliated Union Hospital,Fujian Medical University,Fuzhou 350001,China3.Fuzhou Children Hospital,Fuzhou 350005,China

【机构】 福建医科大学细胞生物学与遗传学系福建医科大学附属协和医院福州市儿童医院 福州350004福州350001福州350004福州350005

【摘要】 目的探讨福州地区5种儿童多基因遗传病(变应性鼻炎、哮喘、特发性性早熟、单纯性肥胖症、特发性矮小症)的发病与结合珠蛋白(Hp)遗传多态的关系。方法应用聚丙烯酰胺凝胶垂直平板电泳技术,分离患者血清中Hp,分析5种患者群体的Hp基因频率和基因型分布,并对5个群体间进行差异比较。结果Hp1基因频率分别为:变应性鼻炎0.387,哮喘0.400,特发性性早熟0.193,单纯性肥胖症0.317,特发性矮小症0.254,正常组0.284。Hp0-0型频率分别为:3.85,0.08,3.85,6.84,3.33,2.40。Hardy-Weinberg遗传平衡分析,除了矮小症群体为非平衡群体外,其他群体均为平衡群体。结论Hp遗传多态与变应性鼻炎、哮喘、特发性性早熟、单纯性肥胖症的发病相关。

【Abstract】 Objective To investigate the relationship between haptoglobin genetic polymorphism(Hp) and five multigenic inherited diseases in children(allergic rhinitis,bronchial asthma,sexual precocity,obesity,short stature).Methods The phenotypes of haptoglobin were studied by means of polyacryamide gel eletrophoresis in five multigenic inherited diseases populations.The Hp gene frequencies of five populations were calculated contrasting with each other and normal controls.Results The Hp1 gene frequencies were allergic rhinitis(0.387),bronchial asthma(0.400),sexual precocity(0.193),obesity(0.317),short stature(0.254),normal controls(0.284).The frequencies of Hp0-0 phenotype were(3.85),0.08,3.85,6.84,3.33 and 2.40,respectively.Hp-type distribution was in agreement with the expectations of a population in Hardy-Weinberg equilibrium in all populations except for short stature.Conclusion Hp genetic polymorphism related to allergic rhinitis,bronchial asthma,sexual precocity and obesity except for short stature.

【基金】 福建省科技厅科研基金资助项目(K02079)
  • 【文献出处】 福建医科大学学报 ,Journal of Fujian Medical University , 编辑部邮箱 ,2006年06期
  • 【分类号】R725.9
  • 【被引频次】5
  • 【下载频次】181
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