【摘要】 通过尾静脉注射四氧嘧啶建立小鼠糖尿病模型,分别用紫球藻胞外多糖按每kg体质量300 m g和150 m g灌胃给药,连续21 d后,分别测定空腹12 h血糖和血浆SOD活性,并观察各组小鼠胰脏组织结构.实验结果显示,与糖尿病模型组相比,紫球藻胞外多糖组小鼠的血糖显著降低(P<0.05),小鼠血浆SOD活性显著升高(P<0.05);紫球藻胞外多糖组小鼠胰脏中胰岛形态结构正常,无纤维化,无出血坏死和明显的炎症细胞浸润.结果表明紫球藻胞外多糖能降低四氧嘧啶糖尿病小鼠血糖并呈现一定的抗氧化能力,对四氧嘧啶所致小鼠胰岛细胞损伤具有修复作用.更多还原

【Abstract】 The diabetic mice model was established by intravenous administration of alloxan,then randomly divided into four groups,two groups were given ig the exopolysaccharide of Porphyridium cruentum 300 mg·kg^-1,150 mg·kg^-1 respectively.After 21 days of treatment,the contents of blood glucose and activities of SOD were detected,the microstructure of pancreas tissues were observed.The results showed that compared with the diabetic model group,the exopolysaccharide of Porphyridium cruentum could significantly decrease the blood glucose of diabetic mice（P<0.05）,the activity of plasma SOD was significantly enhanced（P<0.05）in diabetic mice.For the groups of mice that were given ig exopolysaccharide of Porphyridium cruentum,the pancreatic island cells were normal,and there were not fibrosis cells and hemorrhagic necrosis cells.Therefore,exopolysaccharide of Porphyridium cruentum can reduce the level of blood glucose, effectively enhance the ability of anti-oxidation and protect the pancreas in the diabetic mice induced by alloxan.更多还原