【摘要】 目的了解流脑疫苗接种后的流行新特征。方法在全省4个监测点运用流行病学、微生物学等方法对健康人群做带菌调查和不同时期的抗体水平测定及全省病例进行分析。结果湖北省带菌率为4·33%,带菌以B群为主,发病以A群为主,A群抗体水平较高,C群抗体在疫苗免疫前后有显著性差异,病原株对磺胺类药物100%耐药,对青霉素等7种抗生素均敏感。结论病原株的可能变迁和耐药性对此病需继续加强监测与预防。更多还原

【Abstract】 Objective In order to investigate the change of epidemic features of epidemic cerebrospinal meningitis(ECM) after the implementation of polysaccharide vaccine of Neisseria meningitides(Nm), ECM surveillance has been carried out in four cities (Suizhou,Shiyan,Chibi & Gucheng) for 6 years. Methods Epidemiological and microbiological methods were used.The source, carrying rate of Nm were andlysis, and the GMT of antibody level examined by ELISA. Results The Nm carrying rate was 4.33%, with the Nm serogroup B as the main part. The patients were mainly infected was by Nm serogroup A. The GMT of antibody level of a group was higher than that of the other groups. There was significant difference of Nm serogroup C before and after vaccination. SMZ resistance rate was 100.00%. Susceptibilities to 7 antibiotics including penicillin were high. Conclusion Because of the possible change of pathogenic serogroups and their resistance, surveillance and control of this disease should be strengthened.更多还原